IOWA ONCOLOGY RESEARCH ASSOCIATION
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Lung Cancer Research Studies

EXTENSIVE SMALL CELL
E1508   A Randomized Phase II Study of Cisplatin and Etoposide in Combination with Either Hedgehog Inhibitor GDC-0449 or IGF-1R MOAB IMC-A12 for Patients with Extensive Stage Small Cell Lung Cancer

N0923   A Randomized Double-Blind Phase II Study of NTX-010, a Replication-Competent Picornavirus, After Standard Platinum Containing Induction Regimens of Cytoreductive Chemotherapy for Patients with Extensive Stage Small Cell Lung Cancer

NON-SMALL CELL
C30607    Randomized, Phase III, Placebo-Controlled Trial of Sunitinib as Maintenance Therapy in Non-Progressing Patients Following an Initial Four Cycles of Platinum-Based Combination Chemotherapy in Advanced Stage IIIB / IV Non-Small Cell Lung Cancer 

E1505    Phase III Randomized Trial of Adjuvant Chemotherapy with or without Bevacizumab for Patients with Completely Resected Stage IB (> 4cm)- IIIA Non-Small Cell Lung Cancer

E3508    A Phase II Randomized Trial of Paclitaxel, Carboplatin, Bevacizumab with or without IMC-A12 in Patients with Advanced Non-Squamous, Non-Small Cell Lung Cancer

N0821    A Phase II First-Line Study of a Combination of Pemetrexed, Carboplatin and Bevacizumab in Advanced Nonsquamous NSCLC Evaluating Efficacy and Tolerability in Elderly Patients (age > 70 yrs) with Good Performance Status (PS < 2)

R0617    A Randomized Phase III Comparison of Standard-Dose (60Gy) Versus High-Dose (74Gy) Conformal Radiotherapy with Concurrent and Consolidation Carboplatin / Paclitaxel in Patients with Stage IIIA / IIIB Non-Small Cell Lung Cancer

R0915    A Randomized Phase II Study Comparing Two Stereotactic Body Radiation Therapy (SBRT) Schedules for Medically Inoperable Patients with Stage I Peripheral Non-Small Cell Lung Cancer

S0819    A Randomized Phase III Study Comparing Carboplatin / Paclitaxel or Carboplatin / Paclitaxel / Bevacizumab with or without Concurrent Cetuximab in Patients with Advanced Non-Small Cell Lung Cancer (NSCLC)

ADVANCED NON-SMALL CELL
N0321    Phase I/II Study of PS-341 in Combination with Paclitaxel, Carboplatin, and Concurrent Thoracic Radiation Therapy for Non-small Cell Lung Cancer (NSCLC)

STAGE IV NON-SMALL CELL
N0724   Phase II Study of Oligometastatic Stage IV Non-Small Cell Lung Cancer (NSCLC) Treated with Systemic Therapy Plus Either Radiotherapy to all Sites of Gross Residual Disease or No Radiotherapy

LIMITED SMALL CELL
C30610   Phase III Comparison of Thoracic Radiotherapy Regimens in Patients with Limited Small Cell Lung Cancer also Receiving Cisplatin and Etoposide

CANCER CONTROL
R0517   Randomized Phase III Trial to Evaluate Radiopharmaceuticals and Zoledronic Acid in the Palliation of Osteoblastic Metastases from Lung, Breast, and Prostate Cancer