IOWA ONCOLOGY RESEARCH ASSOCIATION
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Hematologic Cancer Research Studies

ACUTE MYELOID LEUKEMIA
C10603   A Phase III Randomized, Double-Blind Study of Induction (Daunorubicin / Cytarabine) and Consolidation (High-Dose Cytarabine) Chemotherapy + Midostaurin or Placebo in Newly Diagnosed Patients < 60 Years of Age with FLT3 Mutated Acute Myeloid Leukemia (AML)

ACUTE LYMPHOBLASTIC LEUKEMIA
10403   
An Intergroup Phase II Clinical Trial for Adolescents and Young Adults with Untreated Acute Lymphoblatsic Leukemia (ALL)

MYELODYSPLASTIC SYNDROME
E2905   
Randomized Phase III Trial Comparing the Frequency of Major Erythroid Response (MER) to Treatment with Lenalidomide (Revlimid®) Alone and in Combination with Epoetin Alfa (Procrit®) in Subjects with Low- or Intermediate- 1 Risk MDS and Symptomatic Anemia

ACUTE PROMYELOCYTIC LEUKEMIA
S0535   
A Phase II Study of ATRA, Arsenic Trioxide and Gemtuzumab Ozogamicin in Patients with Previously Untreated High-Risk Acute Promyelocytic Leukemia (temporarily suspended)

MANTLE CELL LYMPHOMA
N078D   
Phase I / II Trial of Rituximab, Cladribine, and Temsirolimus (RCT) Therapy in Newly Diagnosed Mantle Cell Lymphoma (MCL)

CHRONIC LYMPHOCYTIC LEUKEMIA
10404   
A Genetic Risk-Stratified Randomized Phase II Study of Four Fludarabine / Antibody Combinations for Patients with Symptomatic, Previously Untreated Chronic Lymphocytic Leukemia

E2903   A Phase II Trial of Pentostatin, Cyclophosphamide and Rituximab (PCR) Followed by Campath-1H for Previously Treated Relapsed of Refractory Patients with Chronic Lymphocytic Leukemia

RC0783   Randomized Phase II Trial of Pentostatin, Cyclophosphamide, and Rituximab with or without Concurrent Avastin® for Previously Untreated B-Chronic Lymphocytic Leukemia (CLL)

MYELOMA
E1A06   An Intergroup Phase III Randomized Controlled Trial Comparing Melphalan, Prednisone and Thalidomide Versus Melphalan, Prednisone and Lenalidomide in Newly Diagnosed Myeloma Patients who are Not Candidates for High-Dose Therapy

CANCER CONTROL
C70604   A Randomized, Phase III Study of Standard Dosing Versus Longer Dosing Interval of Zoledronic Acid in Metastatic Cancer