IOWA ONCOLOGY RESEARCH ASSOCIATION
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Gastrointestinal Research Studies

ESOPHAGEAL
C80101    Phase III Trial of Adjuvant Chemoradiation After Resection of Gastric or Gastroesophageal Adenocarcinoma

R0436    A Phase III Trial Evaluating the Addition of Cetuximab to Paclitaxel, Cisplatin, and Radiation for Patients with Esophageal Cancer who are Treated Without Surgery

ESOPHAGEAL - METASTATIC
E1206   A Randomized Phase II Study of ECF-C, IC-C, or FOLFOX-C in Metastatic Esophageal and GE Junction Cancer

ADJUVANT COLON
E5202   Randomized Phase III Study Comparing 5-FU, Leucovorin and Oxaliplatin VS 5-FU, Leucovorin, Oxaliplatin and Bevacizumab in Patients with Stage II Colon Cancer at High Risk for Recurrence to Determine Prospectively the Prognostic Value of Molecular Markers

N0147   Phase III Trial of Irinotecan (CPT-11) and/or Oxaliplatin Plus 5-Fluorouracil (5-FU) / Leucovorin (CF) with or without Cetuximab (C225) After Curative Resection for Patients with Stage III Colon Cancer (temporarily suspended)

METASTATIC COLORECTAL
C80405   A Phase III Trial of Irinotecan / 5-FU / Leucovorin or Oxaliplatin / 5-FU / Leucovorin with Bevacizumab, or Cetuximab (C225), or with the Combination of Bevacizumab and Cetuximab for Patients with Untreated Metastatic Adenocarcinoma of the Colon or Rectum (temporarily suspended)

E4203   Phase II Study of Treatment Selection Based Upon Tumor Thymidylate Synthase Expression in Previously Untreated Patients with Metastatic Colorectal Cancer (temporarily suspended)

S0600   Phase III Trial of Irinotecan-Based Chemotherapy Plus Cetuximab with or without Bevacizumab as Second-Line Therapy for Patients with Metastatic Colorectal Cancer who have Progressed on Bevacizumab with Either FOLFOX, OPTIMOX or XELOX (temporarily suspended)

RECTAL / ANAL
E5204   Intergroup Randomized Phase III Study of Postoperative Oxaliplatin, f-Flourouracil and Leucovorin vs. Oxaliplatin, 5-Flourouracil, Leucovorin and Bevacizumab for Patients with Stage II or III Rectal Cancer Receiving Pre-operative Chemoradiation

R-04   Clinical Trial Comparing Preoperative Radiation Therapy and Capecitabine with or without OXAL with Preoperative Radiation Therapy and Continuous Intravenous Infusion (CVI) of 5-Fluorouracil (5-FU) with or without OXAL in the Treatment of Patients with Operable Carcinoma of the Rectum

SMALL BOWEL
N0543   A Phase II Trial of Pharmacogenetic-Based Dosing of Irinotecan, Oxaliplatin & Capecitabine as First-Line Therapy for Advanced Small Bowel Adenocarcinoma

GIST
S0502   A Phase III Randomized Trial of Imatinib, with or without Bevacizumab in Patients with Metastatic or Unresectable Gastrointestinal Stromal Tumors