IOWA ONCOLOGY RESEARCH ASSOCIATION
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Brain Cancer Research Studies

NEWLY DIAGNOSED
N057K    Phase I/II Evaluation of Everolimus (RAD001), Radiation and Temozolomide (TMZ) Followed by Adjuvant Temozolomide and Everolimus in Newly Diagnosed Glioblastoma

R0825    Phase III Double-Blind Placebo-Controlled Trial of Conventional Concurrent Chemoradiation and Adjuvant Temozolomide Plus Bevacizumab Versus Conventional Concurrent Chemoradiation and Adjuvant Temozolomide in Patients with Newly Diagnosed Glioblastoma

RECURRENT
N0272    Phase II Trial of Imatinib Mesylate; (Gleevec; STI-571) in Treatment of Recurrent Oligodendroglioma and Mixed Oligoastrocytoma

N0572    A Phase I/II Trial of Sorafenib and CCI-779 in Patients with Recurrent Glioblastoma

N0776    Phase II Trial of Avastin in Combination with Sorafenib in Recurrent Glioblastoma Multiforme (temporarily suspended)

LOW GRADE GLIOMA
E3F05    Phase III Study of Radiation Therapy with or without Temozolomide for Symptomatic or Progressive Low-Grade Glioma

ANAPLASTIC GLIOMA
N0577    Phase III Intergroup Study of Radiotherapy Versus Temozoloimde Alone Versus Radiotherapy with Concomitant and Adjuvant Temozolomide for Patients with 1p/19q Codeleted Anaplastic Glioma

CANCER CONTROL
WFU-91105   Phase III Double-Blind, Placebo-Controlled Study of Donepezil in Irradiated Brain Patients